HRT - Hormone replacement therapy |
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| Mind map HRT - Hormone replacement therapy (from MedMaps.co.uk) - the online mind map resource for medical students and doctors. Gynaecology. Medicine. | |
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HRT
Preparations
Oral
Transdermal
Cream
SC implant (25/50/100 oestradiol)
Benefits/Improvemets of
Headaches 30%
Flushings 77%
insomnia 50%
Depression 30%
Decreases osteoporosis
Cancer
Oestrogens
+- Surgery
+Hysterectomy
.?Colon Ca >5yrs
.?Breast Ca >5 yrs
---Hysterectomy
Needs 12 days/month progestogen
YBreast Ca
.Y Endometrial Ca
.YOvarian Ca
Protrctive against cervical Ca
O+P
Y Breast Ca (< o alone)
Y Endometrial Ca (
Ovarian-no evidence
Protective against cervical
Contraindications
Thromboembolic
Angina
MI
Heart disease
Cancer
Hx f oestrogen depedent
Hepatic
Ritor
Dublin Johnson
Liver disease
Pregnancy
Thromboembolism
oestrogen
>5yrs
.Y Sroke
?NOF
Risk high in 1st 2yrs
o+p
Increased Risk but < estrogen alone
Side Effects
Oestrogen
leg cramps
Progesterone
pre-menstrual syndrome
bloated (slow bowel action)
Both
nausea
breast tenderness
weight gain
fluid retention
slight in crease cholelithiasis
ocasional Y BP
TIBOLINE: (synthetic steroid) Increased risk Breast Ca(HRT), evidence for increased risk of stroke.
NB:ONLY USE HRT +TIBOLOE if LMP >1YR AGO
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